Protein Details: Gamma-aminobutyric acid receptor subunit rho-3

Protein ID

ICDB_Pro_0574

Protein Name

Gamma-aminobutyric acid receptor subunit rho-3

Gene Name

Gabrr3

Organism

Rattus norvegicus (Rat)

Length

464 amino acids

AlphaFoldDB

AF-P50573-F1-model_v4.pdb

Function

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA); the major inhibitory neurotransmitter in the brain. Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits; where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA; rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.

Sequence

MVLAFWLAFFTYTWITLMLDASAVKEPHQQCLSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFIEEFSASSGLAFYSSTGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQTSFFLHSEEDSMRTKFTGSPCADSSQIKRKSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLFYWGIYV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 108; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 172; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain A"; BINDING 200; /ligand="4-aminobutanoate": "ligand shared between two neighboring rho subunits"; /note="in chain B";

Disease

Location

Expressed in retina

DOI ID

10.1016/0167-4781(95)00205-7; 10.1038/sj.bjp.0704432; 10.1074/jbc.m205162200

RefSeq

NP_620252.1